天(tian)然生(sheng)(sheng)物(wu)(wu)(wu)(wu)高(gao)分子膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai)(Collagen)是(shi)動(dong)物(wu)(wu)(wu)(wu)結締組(zu)(zu)織(zhi)(zhi)中(zhong)的(de)主要成(cheng)分,也是(shi)哺乳動(dong)物(wu)(wu)(wu)(wu)體(ti)內(nei)含(han)量(liang)最(zui)(zui)多、分布最(zui)(zui)廣的(de)功能性(xing)(xing)(xing)蛋(dan)(dan)(dan)白(bai)(bai)[1]。因(yin)其(qi)具有(you)(you)良好(hao)的(de)生(sheng)(sheng)物(wu)(wu)(wu)(wu)相(xiang)容(rong)性(xing)(xing)(xing)、營(ying)養(yang)性(xing)(xing)(xing)、修復性(xing)(xing)(xing)、保(bao)濕性(xing)(xing)(xing)、配伍(wu)性(xing)(xing)(xing)和(he)(he)親和(he)(he)性(xing)(xing)(xing),被廣泛應用(yong)于生(sheng)(sheng)物(wu)(wu)(wu)(wu)醫學材料、化妝品(pin)(pin)、食品(pin)(pin)及(ji)(ji)保(bao)健品(pin)(pin)等(deng)(deng)功能性(xing)(xing)(xing)產品(pin)(pin)[2]。目前已有(you)(you)28種類型(xing)(xing)的(de)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai)被發現,其(qi)中(zhong)I型(xing)(xing)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai)的(de)水溶性(xing)(xing)(xing)更(geng)好(hao),生(sheng)(sheng)物(wu)(wu)(wu)(wu)活(huo)性(xing)(xing)(xing)更(geng)高(gao),在(zai)(zai)成(cheng)人(ren)體(ti)內(nei)含(han)量(liang)最(zui)(zui)豐富(fu),起主要作(zuo)(zuo)用(yong),而II型(xing)(xing)和(he)(he)Ⅲ型(xing)(xing)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai),組(zu)(zu)織(zhi)(zhi)含(han)量(liang)相(xiang)對(dui)少(shao),起輔(fu)助和(he)(he)調節作(zuo)(zuo)用(yong)[3]。由于I型(xing)(xing)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai)具有(you)(you)良好(hao)的(de)免(mian)疫(yi)止血、水油(you)平衡、機械力(li)傳(chuan)遞、肌膚更(geng)新、生(sheng)(sheng)物(wu)(wu)(wu)(wu)降解和(he)(he)生(sheng)(sheng)物(wu)(wu)(wu)(wu)相(xiang)容(rong)等(deng)(deng)特性(xing)(xing)(xing),被廣泛應用(yong)于損(sun)傷組(zu)(zu)織(zhi)(zhi)的(de)修復與再(zai)生(sheng)(sheng)[4]。動(dong)物(wu)(wu)(wu)(wu)膠(jiao)(jiao)原的(de)水解產物(wu)(wu)(wu)(wu)便(bian)是(shi)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai),因(yin)此動(dong)物(wu)(wu)(wu)(wu)組(zu)(zu)織(zhi)(zhi)是(shi)人(ren)們獲取天(tian)然膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai)及(ji)(ji)其(qi)膠(jiao)(jiao)原肽的(de)主要途徑,但由于潛在(zai)(zai)的(de)免(mian)疫(yi)原性(xing)(xing)(xing)、動(dong)物(wu)(wu)(wu)(wu)源性(xing)(xing)(xing)疾病、動(dong)物(wu)(wu)(wu)(wu)保(bao)護和(he)(he)某些宗教信仰,限制(zhi)(zhi)了(le)人(ren)們對(dui)陸生(sheng)(sheng)哺乳動(dong)物(wu)(wu)(wu)(wu)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai)及(ji)(ji)其(qi)制(zhi)(zhi)品(pin)(pin)的(de)使用(yong)[5]。而利用(yong)新生(sheng)(sheng)物(wu)(wu)(wu)(wu)技(ji)術制(zhi)(zhi)備的(de)膠(jiao)(jiao)原蛋(dan)(dan)(dan)白(bai)(bai),同樣具有(you)(you)良好(hao)的(de)生(sheng)(sheng)物(wu)(wu)(wu)(wu)相(xiang)容(rong)性(xing)(xing)(xing)、生(sheng)(sheng)物(wu)(wu)(wu)(wu)可降解性(xing)(xing)(xing)和(he)(he)生(sheng)(sheng)物(wu)(wu)(wu)(wu)活(huo)性(xing)(xing)(xing),因(yin)此在(zai)(zai)食品(pin)(pin)、醫藥、組(zu)(zu)織(zhi)(zhi)工程(cheng)、化妝品(pin)(pin)等(deng)(deng)領域(yu)也獲得(de)廣泛應用(yong)[6]。
福(fu)(fu)(fu)萊(lai)明生(sheng)(sheng)(sheng)物(wu)(wu)制藥(yao)聯合(he)廣東(dong)醫(yi)保藥(yao)業有(you)(you)限公(gong)司(si),與(yu)(yu)華南(nan)理工(gong)大學(xue)(xue)(xue)生(sheng)(sheng)(sheng)物(wu)(wu)科(ke)學(xue)(xue)(xue)與(yu)(yu)工(gong)程學(xue)(xue)(xue)院韓教授團隊,以及(ji)香港醫(yi)藥(yao)有(you)(you)限公(gong)司(si)和(he)中華生(sheng)(sheng)(sheng)物(wu)(wu)醫(yi)藥(yao)研(yan)究(jiu)院等(deng)機構的(de)(de)(de)(de)科(ke)學(xue)(xue)(xue)家們,長(chang)期進行(xing)了膠(jiao)(jiao)原(yuan)(yuan)(yuan)蛋白(bai)的(de)(de)(de)(de)應用(yong)(yong)研(yan)究(jiu)。針對人(ren)體皮(pi)膚、肌腱和(he)骨組(zu)織(zhi)等(deng),因(yin)膠(jiao)(jiao)原(yuan)(yuan)(yuan)蛋白(bai)缺(que)失所造成的(de)(de)(de)(de)損傷難(nan)愈、皮(pi)膚松弛(chi)、皺(zhou)紋色斑等(deng)多元(yuan)損傷,我們選擇水(shui)溶性(xing)(xing)更(geng)強、生(sheng)(sheng)(sheng)物(wu)(wu)活(huo)性(xing)(xing)更(geng)高的(de)(de)(de)(de) I 型(xing)和(he) III 型(xing)膠(jiao)(jiao)原(yuan)(yuan)(yuan)蛋白(bai)片段進行(xing)基因(yin)編輯,通過創新(xin)(xin)酶切和(he)獨(du)特的(de)(de)(de)(de)生(sheng)(sheng)(sheng)物(wu)(wu)發酵工(gong)程技術平臺FLM-BioM,開發出一種新(xin)(xin)的(de)(de)(de)(de)重組(zu)人(ren)源(yuan)化 I 型(xing)膠(jiao)(jiao)原(yuan)(yuan)(yuan)功能肽段,命名為:福(fu)(fu)(fu)活(huo)因(yin)子(又名:可溶性(xing)(xing)膠(jiao)(jiao)原(yuan)(yuan)(yuan),注冊商標為:福(fu)(fu)(fu)活(huo)太FHF)。該因(yin)子含有(you)(you)大量親水(shui)性(xing)(xing)結構,與(yu)(yu)周(zhou)圍組(zu)織(zhi)細(xi)胞親和(he)性(xing)(xing)好,具有(you)(you)良(liang)好的(de)(de)(de)(de)成膜性(xing)(xing)與(yu)(yu)組(zu)織(zhi)細(xi)胞支(zhi)撐力(li)(li),可以外源(yuan)補充(chong)方式(shi),通過物(wu)(wu)理作用(yong)(yong)吸(xi)附(fu)于皮(pi)膚和(he)粘(zhan)膜表層,引導上皮(pi)細(xi)胞快(kuai)速遷移至(zhi)受損部(bu)位,參與(yu)(yu)維(wei)持(chi)基底層細(xi)胞結構的(de)(de)(de)(de)完整(zheng)性(xing)(xing),促進皮(pi)膚中膠(jiao)(jiao)原(yuan)(yuan)(yuan)蛋白(bai)的(de)(de)(de)(de)支(zhi)撐張力(li)(li),增強皮(pi)膚緊(jin)致彈性(xing)(xing)。不僅有(you)(you)修(xiu)復(fu)損傷促進愈合(he)功能,還有(you)(you)淡斑除(chu)皺(zhou)、保濕嫩膚的(de)(de)(de)(de)抗衰老作用(yong)(yong)。由福(fu)(fu)(fu)活(huo)因(yin)子衍生(sheng)(sheng)(sheng)的(de)(de)(de)(de)創新(xin)(xin)產品有(you)(you):I 型(xing)膠(jiao)(jiao)原(yuan)(yuan)(yuan)凝(ning)膠(jiao)(jiao)敷(fu)料(liao)、福(fu)(fu)(fu)活(huo)太產后修(xiu)復(fu)凝(ning)膠(jiao)(jiao)、福(fu)(fu)(fu)活(huo)太口腔(qiang)護理膏(gao)、福(fu)(fu)(fu)活(huo)太創傷敷(fu)料(liao)、福(fu)(fu)(fu)活(huo)太痔瘡(chuang)膏(gao)、福(fu)(fu)(fu)活(huo)太微針、福(fu)(fu)(fu)活(huo)太注射劑、福(fu)(fu)(fu)活(huo)太口服(fu)液、福(fu)(fu)(fu)活(huo)太膠(jiao)(jiao)囊(nang)、福(fu)(fu)(fu)活(huo)太面膜等(deng)。
臨(lin)(lin)(lin)床(chuang)實驗(yan)(yan)薈萃分(fen)析證明:基(ji)于膠(jiao)原(yuan)(yuan)蛋白的外用(yong)制(zhi)劑(ji)、植入(ru)物和(he)(he)補充(chong)劑(ji)在各種類(lei)型的創傷修復、骨質再生(sheng)、口腔修復、手術止血和(he)(he)預防感染方(fang)面的臨(lin)(lin)(lin)床(chuang)應(ying)(ying)用(yong)效果顯著,毒副作(zuo)用(yong)較低[7,8]。依據這些臨(lin)(lin)(lin)床(chuang)實驗(yan)(yan)和(he)(he)前期研究成(cheng)果,我們(men)通過(guo)獨(du)特的配方(fang)設(she)計,創造性(xing)將福活因子FHF開發為(wei)針對(dui)陰道松(song)弛(chi)癥狀的新(xin)型治療產品(pin)“ I 型膠(jiao)原(yuan)(yuan)凝(ning)膠(jiao)敷料",并在多家(jia)醫療機構啟動了臨(lin)(lin)(lin)床(chuang)觀察,初步結果證明: I 型膠(jiao)原(yuan)(yuan)凝(ning)膠(jiao)敷料對(dui)于產后或衰老引起的陰道松(song)弛(chi)、陰道萎(wei)縮及應(ying)(ying)激(ji)性(xing)尿失禁(漏尿)具有輔助(zhu)治療作(zuo)用(yong),效果顯著且無不(bu)良反應(ying)(ying)報道,值(zhi)得臨(lin)(lin)(lin)床(chuang)推廣應(ying)(ying)用(yong)。

1. doi:10.1101/cshperspect.a004978
2. doi:10.3390/bioengineering8050063
3. doi: 10.1039/c4sm01772b.
4. Skin collagen through the lifestages: importance for skin health and beauty. Plast Aesthet Res 2021;8:2.
5. doi: 10.1111/jocd.12450.
6. doi: 10.1074/jbc.M110709200.
7. doi: 10.11607/jomi.5461.
8. doi: 10.1111/ijd.15518.